I. Supranuclear Pathway

نویسندگان

  • Byung Hoon Lim
  • Jae Hyoung Kim
  • Sung Hoon Chung
  • Hyung-Jin Kim
چکیده

lated by a high level of coordination between sensory and motor functions which center stationary or moving objects in the central retina (fovea). The securing and stabilization of object images on the fovea during head movement are the basic functions of eye movements (1). Recent advances in the techniques of magnetic resonance (MR) imaging have opened a new horizon for the evaluation of ocular motility disorders; pathologies once considered beyond the scope of imaging are now frequently visualized. Knowledge of the basic pathway and physiology involved in eye movement provides a better understanding of the ocular motility disorders. The supranuclear control of eye movement involves the pathway extending from the cerebral cortex to the ocular motor nuclei located in the brain stem. In this paper, in addition to describing the normal supranuclear pathway of eye movement, we demonstrate MR imaging findings of the typical ocular manifestations caused by disorders involving the supranuclear pathway, providing the anatomic explanations for certain clinical signs.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Combined gaze palsy of horizontal saccades and pursuit contralateral to a midbrain haemorrhage.

A midbrain haemorrhage, revealed by CT, caused a contralateral supranuclear horizontal gaze palsy of both saccades and foveal pursuit. These findings confirm the hypothesis that the supranuclear pathways for pursuit decussate to the contralateral midbrain and then decussate back before innervating the ipsilateral paramedian pontine reticular formation.

متن کامل

Human Wild-Type Tau Interacts with wingless Pathway Components and Produces Neurofibrillary Pathology in Drosophila

Pathologic alterations in the microtubule-associated protein tau have been implicated in a number of neurodegenerative disorders, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP), and frontotemporal dementia (FTD). Here, we show that tau overexpression, in combination with phosphorylation by the Drosophila glycogen synthase kinase-3 (GSK-3) homolog and wingless pathway c...

متن کامل

Sporadic Parkinsonism

Background Differential diagnosis of parkinsonian sindrome is a major challenge in movement disorders because at the onset there is an overlapping of signs and syntoms. From a neuropathological point of view, parkinsonism may be related to a degeneration of the nigrostriatal pathway or the neurodegenerative process may be more widespread [1,2]. In the early course of the a disease presenting wi...

متن کامل

The Topographical Distribution of White Matter Damage in Parkinson’s Disease and Progressive Supranuclear Palsy

Introduction. Progressive supranuclear palsy (PSP) is the second most common cause of neurodegenerativeparkinsonism after idiopathic Parkinson’s disease (PD) [1]. A different ante-mortem distribution of white matter (WM) damage may exist in PD and PSP patients, which might be helpful in the diagnostic work-up of these patients [2]. In this study, we investigated microstructural changes of WM in...

متن کامل

Association of an extended haplotype in the tau gene with progressive supranuclear palsy.

We describe two extended haplotypes that cover the human tau gene. In a total of approximately 200 unrelated caucasian individuals there is complete disequilibrium between polymorphisms which span the gene (which covers approximately 100 kb of DNA). This suggests that the establishment of the two haplotypes was an ancient event and either that recombination is suppressed in this region, or that...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 1999